Catalog Number: 4502
Alternate Names: 3,3-Diindolylmethane
Chemical Name: 3,3'-Methylenediindole
Biological Activity
Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
Technical Data
  • M.Wt:
    246.31
  • Formula:
    C17H14N2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1968-05-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo.
    Kandala et al.
    J.Pharmacol.Exp.Ther., 2012;341:24
  2. Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells.
    Kandala & Srivastava
    Mol.Pharmacol., 2010;78:297
  3. 3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.
    Shorey et al.
    PLoS One., 2012;7:e34975

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