Chemical Name: 3,3'-Methylenediindole
Biological ActivityDIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
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Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo.
Kandala et al.
Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells.
Kandala & Srivastava
3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.
Shorey et al.
PLoS One., 2012;7:e34975
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To determine whether DIM suppressed the activation of EGFR by activating phosphorylation, cells were treated with epidermal growth factor.