DIM
Chemical Name: 3,3'-Methylenediindole
Purity: ≥99%
Biological Activity
Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Blocking epidermal growth factor receptor activation by 3,3'-diindolylmethane suppresses ovarian tumor growth in vitro and in vivo.
Kandala et al.
J.Pharmacol.Exp.Ther., 2012;341:24 -
Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells.
Kandala & Srivastava
Mol.Pharmacol., 2010;78:297 -
3,3'-diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.
Shorey et al.
PLoS One., 2012;7:e34975
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To determine whether DIM suppressed the activation of EGFR by activating phosphorylation, cells were treated with epidermal growth factor.
