DIM

Catalog # Availability Size / Price Qty
4502/50
DIM | CAS No. 1968-05-4 | Cell Cycle Inhibitors
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Description: Inhibits EGFR activation; also induces apoptosis
Alternative Names: 3,3-Diindolylmethane

Chemical Name: 3,3'-Methylenediindole

Purity: ≥99%

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Biological Activity

Activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.

Technical Data

M.Wt:
246.31
Formula:
C17H14N2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1968-05-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Determination of DIM suppression of EGFR
By Anonymous on 12/14/2019
Application: Species: Human

To determine whether DIM suppressed the activation of EGFR by activating phosphorylation, cells were treated with epidermal growth factor.


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