Catalog Number: 0794
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Biological Activity
An irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.
Technical Data
  • M.Wt:
    484.87
  • Formula:
    C22H23Cl2N3OS.HCl
  • Solubility:
    Soluble to 30 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    155512-52-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice.
    Chang et al.
    J.Med.Chem., 1994;37:1547
  2. κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists.
    Chang et al.
    J.Med.Chem., 1994;37:4490
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:

1 Citations: Showing 1 - 1

  1. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
    Authors: Jones Et al.
    Biochem Pharmacol 2010;80:1478

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