Chemical Name: 2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Biological ActivityDipyridamole is a coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).
Fujishige et al.
Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig.
Meester et al.
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
Soderling et al.
Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors.
Lin et al.
Citations for Dipyridamole
The citations listed below are publications that use Tocris products. Selected citations for Dipyridamole include:
3 Citations: Showing 1 - 3
Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass
Authors: Davidson Et al.
PLoS One 2016;11:e0158981
Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism.
Authors: Nguyen Et al.
Pharmacol Res Perspect 2015;3:e00189
Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation.
Authors: Cunha Et al.
Sci Rep 2015;11:215
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