Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50
values are 0.37, 0.38, 0.45, 0.9 and 4.5 μ
M� for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50
= 144.8 nM and Ki
= 8.18 nM for ENT1).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
Soderling et al.
Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).
Fujishige et al.
Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig.
Meester et al.
Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors.
Lin and Buolamwini et al.
The citations listed below are publications that use Tocris products. Selected citations for Dipyridamole include:
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