Catalog Number: 0691
Chemical Name: 2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Biological Activity
Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 μM� for PDE11, 6, 10, 5 and 8 respectively). Inhibits ENT1 and ENT2 (IC50 = 144.8 nM and Ki = 8.18 nM for ENT1).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.
    Soderling et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:8991
  2. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A).
    Fujishige et al.
    J.Biol.Chem., 1999;274:18438
  3. Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig.
    Meester et al.
    Br.J.Pharmacol., 1998;124:729
  4. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors.
    Lin and Buolamwini et al.
    J.Med.Chem., 2007;50:3906

The citations listed below are publications that use Tocris products. Selected citations for Dipyridamole include:

Showing Results 1 - 2 of 2

  1. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass
    Authors: Davidson Et al.
    PLoS One
  2. Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation.
    Authors: Cunha Et al.
    Sci Rep
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