Chemical Name: 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
Biological ActivityDL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages.
Lucy et al.
ACS Chem.Biol, 2019;14:2055
Citation for DL 175
The citations listed below are publications that use Tocris products. Selected citations for DL 175 include:
1 Citation: Showing 1 - 1
Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands.
Authors: Marsango Et al.
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