DL 175

Catalog # Availability Size / Price Qty
7082/10
7082/50
DL 175 | Free Fatty Acid Receptor Agonists
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Description: Potent and selective GPR84 agonist

Chemical Name: 3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

DL 175 is a potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

Technical Data

M.Wt:
299.75
Formula:
C17H14ClNO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for DL 175

The citations listed below are publications that use Tocris products. Selected citations for DL 175 include:

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