Catalog Number: 3154
Alternate Names: DTT, Cleland's reagent, Sputolysin
Chemical Name: threo-1,4-Dimercapto-2,3-butanediol
Biological Activity
Reagent for maintaining SH groups in the reduced state.
Technical Data
  • M.Wt:
    154.25
  • Formula:
    C4H10O2S2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at +4°C
  • CAS No:
    3483-12-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Relative susceptibilities of the interchain disulfides of an immunoglobulin G molecule to reduction by dithiothreitol.
    Sears et al.
    Biochemistry, 1977;16:2031
  2. Reductive cleavage of cystine disulfides with tributylphosphine.
    R?egg and Rudinger
    Methods Enzymol., 1977;47:111
  3. Dithiothreitol, a new protective group for SH groups.
    Cleland
    Biochemistry, 1964;3:480
  4. The effect of thiodiglycol and dithiothreitol on the alkaline hydrolysis products of certain amino acid phenylthiohydantoins.
    Jabusch et al.
    Anal.Biochem., 1978;91:532

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