Catalog Number: 5580
Chemical Name: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Biological Activity
Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
Technical Data
  • M.Wt:
    451.52
  • Formula:
    C27H25N5O2
  • Solubility:
    Soluble to 50 mM in 2eq.HCl and to 20 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1206711-14-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration.
    Tsugawa et al.
    J.Pharmacol.Exp.Ther., 2014;351:549

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