Chemical Name: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Biological ActivityDMH2 is a type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
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Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration.
Tsugawa et al.
Citation for DMH2
The citations listed below are publications that use Tocris products. Selected citations for DMH2 include:
1 Citation: Showing 1 - 1
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
Authors: Stuart Et al.
Cell Stem Cell 2019;25:388
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