DMH2

   
Product Datasheet
Catalog Number:5580
Chemical Name:4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
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Biological Activity
Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
Technical Data
  • M.Wt:
    451.52
  • Formula:
    C27H25N5O2
  • Solubility:
    Soluble to 50 mM in 2eq.HCl and to 20 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1206711-14-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human BMPR-IB/ALK-6 (NP_001194) VersaClone cDNA

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Mouse BMPR-IA/ALK-3 (NP_033888) VersaClone cDNA

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Human BMPR-IA/ALK-3 (NP_004320) VersaClone cDNA

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