Type I BMP receptor inhibitor (Ki
values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki
= 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro
. Enhances liver regeneration in vivo
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All Tocris products are intended for laboratory research use only.
Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration.
Tsugawa et al.