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DMNB

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DMNB | CAS No. 20357-25-9 | DNA-dependent Protein Kinase Inhibitors
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Description: DNA-PK inhibitor

Chemical Name: 4,5-Dimethoxy-2-nitrobenzaldehyde

Purity: ≥98%

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Biological Activity

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

Technical Data

M.Wt:
211.15
Formula:
C9H9NO5
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
20357-25-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Vanillins - a novel family of DNA-PK inhibitors.
    Durant and Karran
    Nucleic Acids Res., 2003;31:5501

Product Datasheets

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