Biological Activity Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
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