Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50
= 15 μ
M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
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All Tocris products are intended for laboratory research use only.
Vanillins - a novel family of DNA-PK inhibitors.
Durant and Karran
Nucleic Acids Res., 2003;31:5501