DMNB

Key Product Details

Product Description

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC₅₀ = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

Product Specifications for DMNB

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DMNB

The following data is based on the product molecular weight 211.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.74 mL	23.68 mL	47.36 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.74 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Durant and Karran Vanillins - a novel family of DNA-PK inhibitors. Nucleic Acids Res. 2003 PMID: 14500812

Product Documents for DMNB