Chemical Name: 4,5-Dimethoxy-2-nitrobenzaldehyde
Biological ActivityInhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Vanillins - a novel family of DNA-PK inhibitors.
Durant and Karran
Nucleic Acids Res., 2003;31:5501
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