DMNB

   
Product Datasheet
Catalog Number:2088
Chemical Name:4,5-Dimethoxy-2-nitrobenzaldehyde
Product Details
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Biological Activity
Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
Technical Data
  • M.Wt:
    211.15
  • Formula:
    C9H9NO5
  • Solubility:
    Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    20357-25-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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