Docetaxel

Catalog # Availability Size / Price Qty
4056/10
4056/50
Microtubule Binding Compounds Small Molecule
1 Image
Description: Microtubule stabilizer

Chemical Name: [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

Purity: ≥99%

Product Details
Citations (4)
Reviews (1)

Biological Activity

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Technical Data

M.Wt:
807.88
Formula:
C43H53NO14
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
114977-28-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Docetaxel: a review of its use in metastatic breast cancer.
    Lyseng-Williamson and Fenton
    Drugs, 2005;65:2513
  2. Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors.
    Ramaswamy and Puhalla
    Drugs Today (Barc), 2006;42:265

Product Datasheets

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Citations for Docetaxel

The citations listed below are publications that use Tocris products. Selected citations for Docetaxel include:

4 Citations: Showing 1 - 4

FAQs

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Reviews for Docetaxel

Average Rating: 5 (Based on 1 Review)

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Positive control for apoptosis
By Anonymous on 12/01/2017
Species: Human

Used as a control to induced apoptosis in cancer cell lines


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