Catalog Number: 4056
Chemical Name: [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih
Biological Activity
Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.
Technical Data
  • M.Wt:
    807.88
  • Formula:
    C43H53NO14
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    114977-28-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Docetaxel: a review of its use in metastatic breast cancer.
    Lyseng-Williamson and Fenton
    Drugs, 2005;65:2513
  2. Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors.
    Ramaswamy and Puhalla
    Drugs Today (Barc), 2006;42:265
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Docetaxel include:

1 Citations: Showing 1 - 1

  1. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther 2017;16(6):1021
Average Rating: 5 (Based on 1 review)

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