Docosahexaenoic acid

Tocris Bioscience | Catalog # 3687

RXR agonist
Tocris Bioscience

Key Product Details

Description

RXR agonist

Alternative Names

DHA
View all Retinoid X Receptor Agonists »

Product Description

Docosahexaenoic acid is a endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.

Product Specifications for Docosahexaenoic acid

Molecular Weight

328.49

Formula

C22H32O2

Storage

Store at -20°C

Purity

≥98%

Chemical Name

(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid

CAS Number

6217-54-5

PubChem ID

445580

InChI Key

MBMBGCFOFBJSGT-KUBAVDMBSA-N

SMILES

CC\C=C/C\C=C/C\C=C/C/C=C\C/C=C\C/C=C\CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.85 100
Ethanol 32.85 100

Preparing Stock Solutions for Docosahexaenoic acid

The following data is based on the product molecular weight 328.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.22 mL 30.44 mL
5 mM 0.61 mL 3.04 mL 6.09 mL
10 mM 0.30 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.30 mL 0.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Docosahexaenoic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Docosahexaenoic acid

For research use only

Citations for Docosahexaenoic acid

Customer Reviews for Docosahexaenoic acid (2)

4 out of 5
2 Customer Ratings
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  • Docosahexaenoic acid
    Name: Chi Ngo
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: human retinal pigment epithelial cells (ARPE-19)
    Verified Customer | Posted 09/07/2025
    I investigated the protective effects of DHA against apoptosis induced by hyperglycemia in human retinal pigment epithelial cells (ARPE-19).
    Docosahexaenoic acid 3687
  • DHA
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Brain Slice
    Verified Customer | Posted 01/31/2018
    DHA used to verify if cells can metabolise various lipids. No effect seen here with DHA but we would need more controls to evaluate the product itself.

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