Catalog Number: 3687
Alternate Names: DHA
Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
Biological Activity
Endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.
    Mata de Urqunia et al.
    Science, 2000;290:2140
  2. Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids.
    Zapata-Gonzalez et al.
    J.Leukoc.Biol., 2008;84:1172
  3. Mechanism of docosahexaenoic acid-induced inhibition of in vitro1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells.
    Hossain et al.
    J.Neurochem., 2009;111:568

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