Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
Biological ActivityEndogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.
Mata de Urqunia et al.
Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids.
Zapata-Gonzalez et al.
Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells.
Hossain et al.
Citations for Docosahexaenoic acid
The citations listed below are publications that use Tocris products. Selected citations for Docosahexaenoic acid include:
3 Citations: Showing 1 - 3
Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer.
Authors: Pal Et al.
J Ovarian Res 2019;12:49
Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells.
Authors: Wnuk Et al.
Mol Neurobiol 2018;55:5059
Phagocytosis-dependent ketogenesis in retinal pigment epithelium.
Authors: Reyes-Reveles Et al.
J Biol Chem 2017;292:8038
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DHA used to verify if cells can metabolise various lipids. No effect seen here with DHA but we would need more controls to evaluate the product itself.