Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
Biological ActivityDocosahexaenoic acid is a endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.
Mata de Urqunia et al.
Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids.
Zapata-Gonzalez et al.
Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells.
Hossain et al.
Citations for Docosahexaenoic acid
The citations listed below are publications that use Tocris products. Selected citations for Docosahexaenoic acid include:
3 Citations: Showing 1 - 3
Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer.
Authors: Pal Et al.
J Ovarian Res 2019;12:49
Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells.
Authors: Wnuk Et al.
Mol Neurobiol 2018;55:5059
Phagocytosis-dependent ketogenesis in retinal pigment epithelium.
Authors: Reyes-Reveles Et al.
J Biol Chem 2017;292:8038
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Docosahexaenoic acid
Average Rating: 3 (Based on 1 Review)
Have you used Docosahexaenoic acid?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
DHA used to verify if cells can metabolise various lipids. No effect seen here with DHA but we would need more controls to evaluate the product itself.