Chemical Name: 4-Iodo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride
Biological ActivityDOI hydrochloride is a brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.
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Effects of serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat.
Monti and Jantos
Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency.
Yu et al.
Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors.
Nelson et al.
Citations for DOI hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DOI hydrochloride include:
4 Citations: Showing 1 - 4
Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.
Authors: Moutkine Et al.
J Biol Chem 2017;292:6352
Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
Authors: Goda Et al.
Psychopharmacology (Berl) 2013;228:271
Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
Authors: Wood Et al.
J Neurosci 2011;31:13808
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Reviews for DOI hydrochloride
Average Rating: 5 (Based on 2 Reviews)
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20mM DOI hydrochloride
I received the product promptly, which is satisfactory in and of itself. In addition, the DOI HCl (>98%) was both pure, and in a form that was convenient for measurement and application. The product was used to determine if non-human animals (in this case, the common mouse) are also capable of receiving hallucinatory/pseud-hallucinatory effects comparable to humans. Tests were based around testing for cognitive, visual, tactile, aural, and gustatory alterations, as well as altered behavioral patterns, not observed in the control group. Tests performed featured experiments (held against behavior of control group) such as: Determining if application of DOI (through careful dissolution in water source) caused altered preference and/or reaction to simulated threats (such as models or pictured of predators), preference regarding food (test group tended to avoid sweet food after consumption during the duration of effects), increase or decrease in sexual behavior (test group showed increased sexual behavior, such as receptivity to intercourse for females and increased mating attempts in males, but decreased competitive/territorial responses to other males), differences in response to auditory cues versus control group (differences noted, but more research required), changes in ability with regards to simple problem-solving versus control (test group showed increased interest and attentiveness to cognitive and sensory stimuli, heightened speed, efficiency, and reflexivity regarding solving simple problems, but agitation or confusion regarding tests involving colors, shapes, sounds, and navigation/stability). Results were promising, but remain inconclusive until more testing and experimentation can be administered. Overall, your product was very satisfactory, and I will certainly continue using your services when needed, and I am more than happy to recommend your services to my colleagues, as well as other biological scientists.