Brain penetrant, mixed 5-HT2A
receptor agonist (Ki
values are 0.7, 2.4 and 20 nM for 5-HT2A
receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A
receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α
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Effects of serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat.
Monti and Jantos
Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency.
Yu et al.
Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors.
Nelson et al.
The citations listed below are publications that use Tocris products. Selected citations for DOI hydrochloride include:
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