Catalog Number: 2643
Alternate Names: (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride
Chemical Name: 4-Iodo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride
Biological Activity
Brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat.
    Monti and Jantos
    Eur.J.Pharmacol., 2006;553:163
  2. Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency.
    Yu et al.
    J.Pharmacol.Exp.Ther., 2008;327:316
  3. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors.
    Nelson et al.
    Naunyn-Schmied.Arch.Pharmacol., 1999;359:1

The citations listed below are publications that use Tocris products. Selected citations for DOI hydrochloride include:

Showing Results 1 - 2 of 2

  1. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
    Authors: Goda Et al.
    Psychopharmacology (Berl)
  2. Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
    Authors: Wood Et al.
    J Neurosci
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