DOI hydrochloride

Catalog # Availability Size / Price Qty
DOI hydrochloride | CAS No. 42203-78-1 | 5-HT2A Receptor Agonists
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Description: 5-HT2A and 5-HT2C agonist
Alternative Names: (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride

Chemical Name: 4-Iodo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride

Purity: ≥98%

Product Details
Citations (4)
Supplemental Products
Reviews (2)

Biological Activity

DOI hydrochloride is a brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.

Technical Data

Soluble to 50 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat.
    Monti and Jantos
    Eur.J.Pharmacol., 2006;553:163
  2. Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency.
    Yu et al.
    J.Pharmacol.Exp.Ther., 2008;327:316
  3. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors.
    Nelson et al.
    Naunyn-Schmied.Arch.Pharmacol., 1999;359:1

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Citations for DOI hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for DOI hydrochloride include:

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Reviews for DOI hydrochloride

Average Rating: 5 (Based on 2 Reviews)

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Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
By Anonymous on 02/03/2020
Application: Species: Mouse

20mM DOI hydrochloride

PMID: 28735749

Superb Experiments Regarding Possibility of Visual/Tactile/Auditory Hallucinatory Effects in Non-Human Animals
By Anonymous on 08/17/2017
Application: Species: Mouse

I received the product promptly, which is satisfactory in and of itself. In addition, the DOI HCl (>98%) was both pure, and in a form that was convenient for measurement and application. The product was used to determine if non-human animals (in this case, the common mouse) are also capable of receiving hallucinatory/pseud-hallucinatory effects comparable to humans. Tests were based around testing for cognitive, visual, tactile, aural, and gustatory alterations, as well as altered behavioral patterns, not observed in the control group. Tests performed featured experiments (held against behavior of control group) such as: Determining if application of DOI (through careful dissolution in water source) caused altered preference and/or reaction to simulated threats (such as models or pictured of predators), preference regarding food (test group tended to avoid sweet food after consumption during the duration of effects), increase or decrease in sexual behavior (test group showed increased sexual behavior, such as receptivity to intercourse for females and increased mating attempts in males, but decreased competitive/territorial responses to other males), differences in response to auditory cues versus control group (differences noted, but more research required), changes in ability with regards to simple problem-solving versus control (test group showed increased interest and attentiveness to cognitive and sensory stimuli, heightened speed, efficiency, and reflexivity regarding solving simple problems, but agitation or confusion regarding tests involving colors, shapes, sounds, and navigation/stability). Results were promising, but remain inconclusive until more testing and experimentation can be administered. Overall, your product was very satisfactory, and I will certainly continue using your services when needed, and I am more than happy to recommend your services to my colleagues, as well as other biological scientists.

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