DOI hydrochloride

Tocris Bioscience | Catalog # 2643

5-HT2A and 5-HT2C agonist
Tocris Bioscience
Discontinued Product
2643 has been discontinued. View all 5-HT2A Receptor Agonists products.

Key Product Details

Description

5-HT2A and 5-HT2C agonist

Alternative Names

(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride
View all 5-HT2A Receptor Agonists »

Product Description

DOI hydrochloride is a brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.

Product Specifications for DOI hydrochloride

Molecular Weight

357.62

Formula

C11H16INO2.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4-Iodo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride

CAS Number

42203-78-1

PubChem ID

170617

InChI Key

QVFDMWGKHUFODK-UHFFFAOYSA-N

SMILES

IC1=C(OC)C=C(CC(C)N)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.88 50

Preparing Stock Solutions for DOI hydrochloride

The following data is based on the product molecular weight 357.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.59 mL 27.96 mL 55.93 mL
2.5 mM 1.12 mL 5.59 mL 11.19 mL
5 mM 0.56 mL 2.80 mL 5.59 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

Product Documents for DOI hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DOI hydrochloride

For research use only

Citations for DOI hydrochloride

Customer Reviews for DOI hydrochloride (2)

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2 Customer Ratings
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  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/03/2020
    20mM DOI hydrochloride
    DOI hydrochloride 2643
  • Superb Experiments Regarding Possibility of Visual/Tactile/Auditory Hallucinatory Effects in Non-Human Animals
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 08/17/2017
    I received the product promptly, which is satisfactory in and of itself. In addition, the DOI HCl (>98%) was both pure, and in a form that was convenient for measurement and application. The product was used to determine if non-human animals (in this case, the common mouse) are also capable of receiving hallucinatory/pseud-hallucinatory effects comparable to humans. Tests were based around testing for cognitive, visual, tactile, aural, and gustatory alterations, as well as altered behavioral patterns, not observed in the control group. Tests performed featured experiments (held against behavior of control group) such as: Determining if application of DOI (through careful dissolution in water source) caused altered preference and/or reaction to simulated threats (such as models or pictured of predators), preference regarding food (test group tended to avoid sweet food after consumption during the duration of effects), increase or decrease in sexual behavior (test group showed increased sexual behavior, such as receptivity to intercourse for females and increased mating attempts in males, but decreased competitive/territorial responses to other males), differences in response to auditory cues versus control group (differences noted, but more research required), changes in ability with regards to simple problem-solving versus control (test group showed increased interest and attentiveness to cognitive and sensory stimuli, heightened speed, efficiency, and reflexivity regarding solving simple problems, but agitation or confusion regarding tests involving colors, shapes, sounds, and navigation/stability). Results were promising, but remain inconclusive until more testing and experimentation can be administered. Overall, your product was very satisfactory, and I will certainly continue using your services when needed, and I am more than happy to recommend your services to my colleagues, as well as other biological scientists.

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