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DOI hydrochloride

Catalog #: 2643
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2643/10
2643/50
DOI hydrochloride | CAS No. 42203-78-1 | 5-HT2A Receptor Agonists
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Description: 5-HT2A and 5-HT2C agonist
Alternative Names: (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride

Chemical Name: 4-Iodo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity

DOI hydrochloride is a brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.

Technical Data

M.Wt:
357.62
Formula:
C11H16INO2.HCl
Solubility:
Soluble to 50 mM in water
Purity:
≥98%
Storage:
Store at RT
CAS No:
42203-78-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat.
    Monti and Jantos
    Eur.J.Pharmacol., 2006;553:163
  2. Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency.
    Yu et al.
    J.Pharmacol.Exp.Ther., 2008;327:316
  3. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors.
    Nelson et al.
    Naunyn-Schmied.Arch.Pharmacol., 1999;359:1

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Citations for DOI hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for DOI hydrochloride include:

4 Citations: Showing 1 - 4

  1. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
    Authors: Medrihan Et al.
    Neuron  2017;95:564
  2. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.
    Authors: Moutkine Et al.
    J Biol Chem  2017;292:6352
  3. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
    Authors: Goda Et al.
    Psychopharmacology (Berl)  2013;228:271
  4. Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production.
    Authors: Wood Et al.
    J Neurosci  2011;31:13808

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VersaClone cDNA Plasmids

Human 5-HT2A (NP_000612) VersaClone cDNA

RDC0288

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