Chemical Name: 3,4-Dihydroxyphenethylamine hydrochloride
Biological ActivityEndogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis. Caged dopamine is also available (Cat. No 3992).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel insights into DA receptor pharmacology.
Rivonello et al.
Role of DA in the motivational and cognitive control of behavior.
Prolactin and DA: what is the connection? A review article.
Fitzgerald and Dinan
Citations for Dopamine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Dopamine hydrochloride include:
8 Citations: Showing 1 - 8
DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. 2017;16(6):1323
Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
Retroactive modulation of spike timing-dependent plasticity by DA.
Authors: Brzosko Et al.
Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
Attenuated DArgic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
Authors: Zheng Et al.
Physiol Res 2014;306:R138
Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians.
Authors: Zhang Et al.
Physiol Behav 2013;112-113:8
Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs.
Authors: Kucka Et al.
World J Gastroenterol 2012;61:267
DA-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF.
Authors: O'Keeffe Et al.
Proc Natl Acad Sci U S A 2009;106:8754
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