Catalog Number: 3548
Chemical Name: 3,4-Dihydroxyphenethylamine hydrochloride
Biological Activity
Endogenous neurotransmitter that acts as an agonist at dopamine D1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis. Caged dopamine is also available (Cat. No 3992).
Technical Data
  • M.Wt:
    189.64
  • Formula:
    C8H11NO2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    62-31-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel insights into dopamine receptor pharmacology.
    Rivonello et al.
    Eur.J.Endocrinol., 2007;156:S13
  2. Role of dopamine in the motivational and cognitive control of behavior.
    Cools
    Neuroscientist, 2008;14:381
  3. Prolactin and dopamine: what is the connection? A review article.
    Fitzgerald and Dinan
    J.Psychopharmacol., 2008;22:S12
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dopamine hydrochloride include:

8 Citations: Showing 1 - 8
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  1. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. 2017;16(6):1323
  2. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci 2015;9:192
  3. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
    Elife 2015;4
  4. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  5. Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes.
    Authors: Zheng Et al.
    Physiol Res 2014;306:R138
  6. Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians.
    Authors: Zhang Et al.
    Physiol Behav 2013;112-113:8
  7. Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs.
    Authors: Kucka Et al.
    World J Gastroenterol 2012;61:267
  8. Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF.
    Authors: O'Keeffe Et al.
    Proc Natl Acad Sci U S A 2009;106:8754

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