DOTAP

Key Product Details

Product Description

DOTAP is a cationic agent used in liposome formation. Facilitates the transfection of DNA, RNA, and other molecules with negative charges into eukaryotic cells. Can be used to generate selective organ-targeting (SORT) lipid nanoparticles.

For more information on how to prepare MC3 lipid nanoparticles for RNA delivery, please see our protocol.

Product Specifications for DOTAP

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DOTAP

The following data is based on the product molecular weight 698.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.43 mL	7.16 mL	14.32 mL
5 mM	0.29 mL	1.43 mL	2.86 mL
10 mM	0.14 mL	0.72 mL	1.43 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. Nat.Protoc. 2023 PMID: 36316378

Product Documents for DOTAP