Chemical Name: (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate
Biological ActivityDoxycycline hyclate is a broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Doxycycline hyclate increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.
For more information about how Doxycycline hyclate may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Reprogramming MEFs into Skeletal Muscle Progenitors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.
Wernig et al.
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices.
Franco et al.
Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia.
Burggraf et al.
Citations for Doxycycline hyclate
The citations listed below are publications that use Tocris products. Selected citations for Doxycycline hyclate include:
2 Citations: Showing 1 - 2
Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.
Authors: Sato Et al.
Stem Cell Reports 2019;13:352
Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.
Authors: Kalous Et al.
J Neurochem 2012;122:523
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