Catalog Number: 4090
Chemical Name: (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate
Biological Activity
Broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.
Technical Data
  • M.Wt:
    512.94
  • Formula:
    C22H24N2O8.HCl.0.5C2H6O.0.5H2O
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    24390-14-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices.
    Franco et al.
    Am.J.Pathol., 2006;168:1697
  2. Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia.
    Burggraf et al.
    Neurobiol.Dis., 2007;25:506
  3. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.
    Wernig et al.
    Nat.Biotechnol., 2008;26:916
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Doxycycline hyclate include:

1 Citations: Showing 1 - 1

  1. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF.
    Authors: Kalous Et al.
    J Neurochem 2012;122:523

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