DPO-1

  ( 4 citations )    
Product Datasheet
Catalog Number:2533
Alternate Names:Diphenyl phosphine oxide-1
Chemical Name:[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
Product Details
Citations (4)
Reviews
Biological Activity
Blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
Technical Data
  • M.Wt:
    340.44
  • Formula:
    C22H29OP
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    43077-30-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DPO-1 include:

4 Citations: Showing 1 - 4
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  1. Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.
    Authors: Ryland Et al.
    Oncogene  2015;34:4591
  2. Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit.
    Authors: Tabarean
    Pharmacol Res Perspect  2014;9:e96643
  3. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.
    Authors: Zhao Et al.
    PLoS One  2013;8:e64629
  4. Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.
    Authors: Haim Et al.
    J Mol Cell Cardiol  2010;48:395

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