Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
Biological ActivityDPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide.
Stump et al.
In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate.
Regan et al.
Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapid activating delayed rectifier potassium current.
Lagrutta et al.
Citations for DPO-1
The citations listed below are publications that use Tocris products. Selected citations for DPO-1 include:
5 Citations: Showing 1 - 5
Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation.
Authors: Ryland Et al.
Mol Cancer Res 2016;14:26
Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress.
Authors: Ryland Et al.
Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit.
Pharmacol Res Perspect 2014;9:e96643
Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.
Authors: Zhao Et al.
PLoS One 2013;8:e64629
Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.
Authors: Haim Et al.
J Mol Cell Cardiol 2010;48:395
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Reviews for DPO-1
Average Rating: 5 (Based on 1 Review)
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DPO 1 was used to investigate its effect on Kv channels at different concentrations. Its shows increasing blocking effect on the channels with increasing concentrations. Worked ideally during the study and would recommend the product.