Catalog Number: 2533
Alternate Names: Diphenyl phosphine oxide-1
Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
Biological Activity
Blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
Technical Data
  • M.Wt:
    340.44
  • Formula:
    C22H29OP
  • Solubility:
    Soluble to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    43077-30-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide.
    Stump et al.
    J.Pharmacol.Exp.Ther., 2005;315:1362
  2. In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate.
    Regan et al.
    J.Pharmacol.Exp.Ther., 2006;316:727
  3. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapid activating delayed rectifier potassium current.
    Lagrutta et al.
    J.Pharmacol.Exp.Ther., 2006;317:1054
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DPO-1 include:

3 Citations: Showing 1 - 3
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  1. Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit.
    Authors: Tabarean
    Pharmacol Res Perspect 2014;9:e96643
  2. Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.
    Authors: Zhao Et al.
    PLoS One 2013;8:e64629
  3. Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.
    Authors: Haim Et al.
    J Mol Cell Cardiol 2010;48:395

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