DPO-1

Tocris Bioscience | Catalog # 2533

Blocker of KV1.5 channel and IKur current
Tocris Bioscience

Key Product Details

Description

Blocker of KV1.5 channel and IKur current

Alternative Names

Diphenyl phosphine oxide-1
View all Voltage-gated Potassium Channel Blockers »

Product Description

DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Product Specifications for DPO-1

Molecular Weight

340.44

Formula

C22H29OP

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide

CAS Number

43077-30-1

PubChem ID

21678144

InChI Key

BPCNGVCAHAIZEE-COPCDDAFSA-N

SMILES

C[C@@H]1CC[C@@H]([C@@H](C)C)[C@@H]([P@@](C2=CC=CC=C2)(C3=CC=CC=C3)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 34.04 100

Preparing Stock Solutions for DPO-1

The following data is based on the product molecular weight 340.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.37 mL
5 mM 0.59 mL 2.94 mL 5.87 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

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Product Documents for DPO-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DPO-1

For research use only

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  • DPO 1 was used to investigate its effect on Kv channels at different concentrations
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/29/2018
    DPO 1 was used to investigate its effect on Kv channels at different concentrations. Its shows increasing blocking effect on the channels with increasing concentrations. Worked ideally during the study and would recommend the product.
    DPO-1 2533

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