DPO-1

Catalog # Availability Size / Price Qty
2533/10
2533/50
DPO-1 | CAS No. 43077-30-1 | Voltage-gated Potassium Channel Blockers
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Description: Blocker of KV1.5 channel and IKur current
Alternative Names: Diphenyl phosphine oxide-1

Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide

Purity: ≥99%

Product Details
Citations (5)
Reviews (1)

Biological Activity

Blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Technical Data

M.Wt:
340.44
Formula:
C22H29OP
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
43077-30-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DPO-1

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5 Citations: Showing 1 - 5

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DPO 1 was used to investigate its effect on Kv channels at different concentrations
By Anonymous on 10/29/2018
Species: Human

DPO 1 was used to investigate its effect on Kv channels at different concentrations. Its shows increasing blocking effect on the channels with increasing concentrations. Worked ideally during the study and would recommend the product.


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