Catalog Number: 2783
Chemical Name: 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride
Biological Activity
Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.
Technical Data
  • M.Wt:
    312.8
  • Formula:
    C14H20N4O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    866396-70-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.
    Wright et al.
    J.Med.Chem., 2006;49:3068

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