Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50
= 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50
> 30 μ
M). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.
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All Tocris products are intended for laboratory research use only.
cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.
Wright et al.