Potent TLR7 agonist (EC50
= 7.2 nM). Activates several immune effector cells in vitro
. Suppresses metastasis in vivo
and enhances efficacy of radiation therapy in a model of colorectal carcinoma.
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All Tocris products are intended for laboratory research use only.
A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models.
Adlard et al.
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
Nakamura et al.