dTRIM 24

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dTRIM 24 | CAS No. 2170695-14-2 | Active Degraders
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Description: TRIM24 Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

dTRIM 24 is a degrader (PROTAC®) composed of the TRIM24 ligand IACS-9571 conjugated to a VHL ligand. Displays dose- and time-dependent degradation of TRIM24 in cells, with maximum degradation achieved at 5 μM. Degradation phenotypically mirrors genetic deletion of TRIM24. Demonstrates antiproliferative effects in MOLM-13 cells. Cell permeable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Soluble to 20 mM in DMSO and to 20 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
    Gechijian et al.
    Nat.Chem.Biol., 2018;14:405

Product Datasheets

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Citation for dTRIM 24

The citations listed below are publications that use Tocris products. Selected citations for dTRIM 24 include:

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