DV 7028 hydrochloride

Catalog # Availability Size / Price Qty
4480/10
4480/50
Cat.No. 4480 - DV 7028 hydrochloride | C21H25FN4O3.HCl | CAS No. 133364-62-2
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Description: Selective 5-HT2A antagonist; antithrombotic

Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione hydrochloride

Purity: ≥99%

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Biological Activity

Selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Exhibits no affinity for 5-HT1A, 5-HT1B or 5-HT1D receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models.

Technical Data

M.Wt:
436.91
Formula:
C21H25FN4O3.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 10 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
133364-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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