DV 7028 hydrochloride

Key Product Details

Product Description

DV 7028 hydrochloride is a selective 5-HT_2A receptor antagonist (K_i = 22 nM for at 5-HT₂ receptors). Exhibits no affinity for 5-HT_1A, 5-HT_1B or 5-HT_1D receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models.

Product Specifications for DV 7028 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DV 7028 hydrochloride

The following data is based on the product molecular weight 436.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.89 mL	114.44 mL	228.88 mL
0.5 mM	4.58 mL	22.89 mL	45.78 mL
1 mM	2.29 mL	11.44 mL	22.89 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Shibano Pharmacological profile of a new 5-hydroxytryptamine 2 receptor antagonist, DV-7028. Arch.Int.Pharmacodyn.Ther. 1992 PMID: 1285670
• Pawlak A potent 5-hydroxytryptamine receptor (5-HT_2A) antagonist, DV-7028, delays arterial thrombosis development in rats. Thromb.Res. 1998 PMID: 9700856

Product Documents for DV 7028 hydrochloride