receptor antagonist (Ki
= 22 nM for at 5-HT2
receptors). Exhibits no affinity for 5-HT1A
receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models.
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All Tocris products are intended for laboratory research use only.
A potent 5-hydroxytryptamine receptor (5-HT2A) antagonist, DV-7028, delays arterial thrombosis development in rats.
Pawlak et al.
Pharmacological profile of a new 5-hydroxytryptamine 2 receptor antagonist, DV-7028.
Shibano et al.