Dynapyrazole A

Key Product Details

Product Description

Dynapyrazole A is a dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC₅₀ values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC₅₀ = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.

Product Specifications for Dynapyrazole A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Dynapyrazole A

The following data is based on the product molecular weight 486.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.27 mL	51.37 mL	102.73 mL
1 mM	2.05 mL	10.27 mL	20.55 mL
2 mM	1.03 mL	5.14 mL	10.27 mL
10 mM	0.21 mL	1.03 mL	2.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Steinman Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. Elife 2017 PMID: 28524820

Product Documents for Dynapyrazole A