Dynarrestin

Key Product Details

Product Description

Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC₅₀ = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.

Product Specifications for Dynarrestin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Dynarrestin

The following data is based on the product molecular weight 431.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.17 mL
5 mM	0.46 mL	2.32 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Höing Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 2018 PMID: 29396292

Product Documents for Dynarrestin