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Dynarrestin

Catalog #: 6526 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6526/5
Dynarrestin | CAS No. 2222768-84-3 | Hedgehog Signaling Inhibitors
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Description: Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein

Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate

Purity: ≥98%

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Biological Activity

Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.

Technical Data

M.Wt:
431.5
Formula:
C22H23F2N3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2222768-84-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Experiment

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Background References

  1. Dynarrestin, a novel inhibitor or cytoplasmic dynein.
    Höing et al.
    Cell Chem.Biol., 2018;25:357

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