Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
Biological ActivityDynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Dynarrestin, a novel inhibitor or cytoplasmic dynein.
Höing et al.
Cell Chem.Biol., 2018;25:357
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