Catalog Number: 4222
Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Biological Activity
Dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles.
    Hill et al.
    J.Med.Chem., 2009;52:3762
  2. Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.
    Hill et al.
    J.Med.Chem., 2010;53:4094

The citations listed below are publications that use Tocris products. Selected citations for Dynole 34-2 include:

Showing Results 1 - 1 of 1

  1. Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors.
    Authors: Han Et al.
    Am J Physiol Cell Physiol
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