Dynole 34-2 (CAS 1128165-88-7): R&D Systems
Catalog Number: 4222
Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Biological Activity
Dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).
Technical Data
  • M.Wt:
    408.58
  • Formula:
    C25H36N4O
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1128165-88-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles.
    Hill et al.
    J.Med.Chem., 2009;52:3762
  2. Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.
    Hill et al.
    J.Med.Chem., 2010;53:4094
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dynole 34-2 include:

2 Citations: Showing 1 - 2
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  1. Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements.
    Authors: Lasic
    Biochim Biophys Acta 2017;1861(9):2293
  2. Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors.
    Authors: Han Et al.
    Am J Physiol Cell Physiol 2015;290:325

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