Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Biological ActivityDynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles.
Hill et al.
Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis.
Hill et al.
Citations for Dynole 34-2
The citations listed below are publications that use Tocris products. Selected citations for Dynole 34-2 include:
2 Citations: Showing 1 - 2
Dynamin regulates the fusion pore of endo- and exocytotic vesicles as revealed by membrane capacitance measurements.
Biochim Biophys Acta 2017;1861(9):2293
Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors.
Authors: Han Et al.
Am J Physiol Cell Physiol 2015;290:325
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