Chemical Name: 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide
Biological ActivityE 7820 is a α2 integrin inhibitor. Inhibits angiogenesis in vitro (IC50 = 0.11 - 0.25 μM). Also inhibits growth of human colorectal cancer cell lines. Enhances efficacy of erlotinib in a non-small-cell lung cancer xenograft model. Also acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin α2 subunit on endothelium.
Funahashi et al.
Cancer Res., 2002;62:6116
Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models.
Ito et al.
Cancer Sci., 2014;105:1023
Selective degradation of splicing factor CAPERα by anticancer sulfonamides.
Uehara et al.
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