Catalog Number: 3882
Chemical Name: (E)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one
Biological Activity
Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.

Geometric Isomer also available.

Technical Data
  • M.Wt:
    329.17
  • Formula:
    C19H15FeNO
  • Solubility:
    Soluble to 5 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    884338-18-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors.
    Spencer et al.
    Metallomics, 2011;3:600
  2. Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.
    Spencer et al.
    Dalton Transact., 2009;6:918

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