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(Z)-FeCP-oxindole

3883 Datasheet / COA / SDS
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3883/10
(Z)-FeCP-oxindole | CAS No. 1137967-28-2 | VEGF Receptor Inhibitors
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Description: Selective VEGFR-2 inhibitor

Chemical Name: (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one

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Biological Activity

Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.

Geometric Isomer also available.

Technical Data

M.Wt:
329.17
Formula:
C19H15FeNO
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Storage:
Store at +4°C
CAS No:
1137967-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
    Spencer et al.
    Metallomics, 2011;3:600
  2. Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.
    Spencer et al.
    Dalton Transact., 2009;6:918

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VersaClone cDNA Plasmids

Human VEGFR2/KDR/Flk-1 (AAC16450) VersaClone cDNA

RDC0467

Mouse VEGFR2/KDR/Flk-1 (NP_034742) VersaClone cDNA

RDC1823

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