(Z)-FeCP-oxindole
1 Image
Description: Selective VEGFR-2 inhibitor
Chemical Name: (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one
Biological Activity
Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.Geometric Isomer also available.
Technical Data
M.Wt:
329.17
Formula:
C19H15FeNO
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Storage:
Store at +4°C
CAS No:
1137967-28-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Other Product-Specific Information:
Background References
-
Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
Spencer et al.
Metallomics, 2011;3:600 -
Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.
Spencer et al.
Dalton Transact., 2009;6:918
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for (Z)-FeCP-oxindole
There are currently no reviews for this product. Be the first to review (Z)-FeCP-oxindole and earn rewards!
Have you used (Z)-FeCP-oxindole?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive
tools for
life science research with over 30 years' experience in the
industry.
Tocris is a Bio-Techne brand.
