Eact

Catalog # Availability Size / Price Qty
4876/10
4876/50
Cat.No. 4876 - Eact | C22H24N2O5S | CAS No. 461000-66-8
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Description: Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)

Chemical Name: 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide

Product Details
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Biological Activity

TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). Ca2+-independent. Displays no effect on CFTR Cl- or ENaC Na+ conductance. Stimulates submucosal gland secretion in human bronchi.

Technical Data

Formula:
C22H24N2O5S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
461000-66-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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