TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50
= 3 μ
-independent. Displays no effect on CFTR Cl-
or ENaC Na+
conductance. Stimulates submucosal gland secretion in human bronchi.
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Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.
Namkung W, Yao Z, Finkbeiner WE, Verkman AS.