Eact

Key Product Details

Product Description

Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC₅₀ = 3 μM). Also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC₅₀ = 11.6 μM). Ca²⁺-independent. Displays no effect on CFTR Cl^- or ENaC Na⁺ conductance. Stimulates submucosal gland secretion in human bronchi.

Product Specifications for Eact

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Eact

The following data is based on the product molecular weight 428.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Liu Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours. Br.J.Pharmacol. 2016 PMID: 26756551
• Namkung Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 2011 PMID: 21836025

Product Documents for Eact