EB 47

Tocris Bioscience | Catalog # 4140

Potent PARP-1 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent PARP-1 inhibitor
View all Poly(ADP-ribose) Polymerase Inhibitors »

Product Description

EB 47 is a potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.

Product Specifications for EB 47

Molecular Weight

610.45

Formula

C24H27N9O6.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride

CAS Number

1190332-25-2

PubChem ID

90488915

InChI Key

VVMQSDIMNDTMII-MYXHFVDASA-N

SMILES

NC1=C2N=CN([C@@H]3O[C@@H]([C@@H](O)[C@H]3O)C(N4CCN(CC(NC5=C6CNC(C6=CC=C5)=O)=O)CC4)=O)C2=NC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.05 5 with gentle warming
DMSO 30.52 50

Preparing Stock Solutions for EB 47

The following data is based on the product molecular weight 610.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.28 mL 16.38 mL 32.76 mL
2.5 mM 0.66 mL 3.28 mL 6.55 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
25 mM 0.07 mL 0.33 mL 0.66 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for EB 47

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EB 47

For research use only

Related Research Areas

Apoptosis

Customer Reviews for EB 47 (1)

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  • EB47 inhibits PARP1 PARylation
    Name: Paras Gaur
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: human proteins
    Verified Customer | Posted 02/05/2025
    We utilized this product in our lab to inhibit PARP1 PARylation and observed effective inhibition in our single-molecule Mass Photometry experiments at a concentration of 75 nM.
    EB 47 4140

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