EB 47

  ( 3 citations )    
Product Datasheet
Catalog Number:4140
Chemical Name:5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride
Product Details
Citations (3)
Reviews
Biological Activity
Potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.
Technical Data
  • M.Wt:
    610.45
  • Formula:
    C24H27N9O6.2HCl
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    1190332-25-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for EB 47 include:

3 Citations: Showing 1 - 3
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  1. PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier
    Authors: Rom Et al.
    Journal of Neuroinflammation  2016;13:254
  2. The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.
    Authors: Rom Et al.
    Dev Biol  2015;6:878
  3. Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions.
    Authors: Rom Et al.
    Front Microbiol  2015;35:28

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