Catalog Number: 5245
Chemical Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Biological Activity
Glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. Antioxidant and anti-inflammatory.
Technical Data
  • M.Wt:
    274.18
  • Formula:
    C13H9NOSe
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    60940-34-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Molecular actions of ebselen--an antiinflammatory antioxidant.
    Schewe
    Gen.Pharmacol., 1995;26:1153
  2. Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats.
    Yang et al.
    Carcinogenesis, 2000;21:2237
  3. Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound.
    Fujisawa and Kadoma
    Anticancer Res., 2005;25:3989

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