Edaravone

Key Product Details

Product Description

Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

Product Specifications for Edaravone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Edaravone

The following data is based on the product molecular weight 174.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.74 mL	28.70 mL	57.41 mL
5 mM	1.15 mL	5.74 mL	11.48 mL
10 mM	0.57 mL	2.87 mL	5.74 mL
50 mM	0.11 mL	0.57 mL	1.15 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
• Kawasaki Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 2007 PMID: 17429058
• Watanabe Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 1994 PMID: 8138971
• Kawai Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 1997 PMID: 9152402

Product Documents for Edaravone