hh Edaravone (CAS 89-25-8): R&D Systems
Catalog Number: 0786
Alternate Names: MCI-186
Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one
Biological Activity
A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.
Technical Data
  • M.Wt:
    174.2
  • Formula:
    C10H10N2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    89-25-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model.
    Kawai et al.
    J.Pharmacol.Exp.Ther., 1997;281:921
  2. Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.
    Kawasaki et al.
    J.Pharmacol.Exp.Ther., 2007;322:274
  3. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.
    Watanabe et al.
    J.Pharmacol.Exp.Ther., 1994;268:1597
  4. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Edaravone include:

2 Citations: Showing 1 - 2
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  1. Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.
    Authors: Tsunekawa Et al.
    Br J Pharmacol 2013;14:4
  2. Adult neurogenesis transiently generates oxidative stress.
    Authors: Walton Et al.
    PLoS One 2012;7:e35264

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