Edaravone
Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one
Purity: ≥99%
Biological Activity
Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Nat.Rev.Drug.Discov., 2017; -
Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model.
Kawai et al.
J.Pharmacol.Exp.Ther., 1997;281:921 -
Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.
Kawasaki et al.
J.Pharmacol.Exp.Ther., 2007;322:274 -
Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.
Watanabe et al.
J.Pharmacol.Exp.Ther., 1994;268:1597
Product Datasheets
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Citations for Edaravone
The citations listed below are publications that use Tocris products. Selected citations for Edaravone include:
3 Citations: Showing 1 - 3
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Phorbol ester-induced angiogenesis of endothelial progenitor cells: The role of NADPH oxidase-mediated, redox-related matrix metalloproteinase pathways.
Authors: Wu Et al.
PLoS One 2019;14:e0209426
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Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.
Authors: Tsunekawa Et al.
Br J Pharmacol 2013;14:4
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Adult neurogenesis transiently generates oxidative stress.
Authors: Walton Et al.
PLoS One 2012;7:e35264
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