EG 00229 trifluoroacetate

Catalog # Availability Size / Price Qty
6986/10
VEGF Receptor Inhibitors Small Molecule
1 Image
Description: Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

Chemical Name: N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate

Purity: ≥98%

Product Details
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Biological Activity

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro.

Technical Data

M.Wt:
611.59
Formula:
C17H19N7O5S3.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1210945-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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