EG 00229 trifluoroacetate

Tocris Bioscience | Catalog # 6986

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
Tocris Bioscience

Key Product Details

Description

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
View all VEGF Receptor Inhibitors »

Product Description

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

Product Specifications for EG 00229 trifluoroacetate

Molecular Weight

611.59

Formula

C17H19N7O5S3.CF3CO2H

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate

CAS Number

1210945-69-9

PubChem ID

45142253

InChI Key

ZYQBITUOSRZDTG-MERQFXBCSA-N

SMILES

O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq. NaOH 61.16 100
DMSO 61.16 100

Preparing Stock Solutions for EG 00229 trifluoroacetate

The following data is based on the product molecular weight 611.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.18 mL 16.35 mL
5 mM 0.33 mL 1.64 mL 3.27 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for EG 00229 trifluoroacetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EG 00229 trifluoroacetate

For research use only

Citations for EG 00229 trifluoroacetate

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