EG 00229 trifluoroacetate

Catalog # Availability Size / Price Qty
EG 00229 trifluoroacetate | CAS No. 1210945-69-9 | VEGF Receptor Inhibitors
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Description: Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1

Chemical Name: N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for EG 00229 trifluoroacetate

The citations listed below are publications that use Tocris products. Selected citations for EG 00229 trifluoroacetate include:

1 Citation: Showing 1 - 1

  1. Neuropilin-1 is a host factor for SARS-CoV-2 infection.
    Authors: Daly Et al.
    Science  2020;370:861


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