Chemical Name: Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid
Biological ActivityCalcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes.
Boullerne et al.
Catalytic superoxide scavenging by metal complexes of the calcium chelator EGTA and contrast agent EHPG.
Fisher et al.
Citations for EGTA
The citations listed below are publications that use Tocris products. Selected citations for EGTA include:
6 Citations: Showing 1 - 6
Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia.
Authors: Ahn Et al.
TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
Authors: Shambharkar Et al.
BMC Complement Altern Med 2015;10:e0127480
Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
Authors: Chang Et al.
PLoS One 2013;34:1096
On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
Authors: Gouet Et al.
PLoS One 2012;7:e49293
Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition.
Authors: Zhang Et al.
Biochim Biophys Acta 2011;1808:1993
Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
Authors: Lerner Et al.
J Neurosci 2010;30:2160
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ER Ca2+ in HEK293 cells co-expressing YFP-STIM1 and Orai1-CFP was passively depleted with pipette solution, containing (in mM): 20 EGTA, 145 Cs-methanesulfonate, 8 NaCl, 5 MgCl2 and 10 HEPES, pH 7.2 with KOH.
HL-1 cells were incubated with EGTA (5 mM) for 30 min prior to 15d-PGJ2 (15 µM) treatment for 4 h to follow TNFa concentrations in the cell culture medium. Addition of EGTA resulted in abolition of 15d-PGJ2 induced TNFa production.