Catalog Number: 2807
Chemical Name: Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid
Biological Activity
Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.
Technical Data
  • M.Wt:
    380.35
  • Formula:
    C14H24N2O10
  • Solubility:
    Soluble to 100 mM in 1M NaOH
  • Storage:
    Store at RT
  • CAS No:
    67-42-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes.
    Boullerne et al.
    J.Neurosci.Res., 2001;63:124
  2. Catalytic superoxide scavenging by metal complexes of the calcium chelator EGTA and contrast agent EHPG.
    Fisher et al.
    Biochem.Biophy.Res.Comms., 2004;323:163
Citations:

The citations listed below are publications that use Tocris products. Selected citations for EGTA include:

3 Citations: Showing 1 - 3
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  1. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia.
    Authors: Ahn Et al.
    Carcinogenesis 2015;15:202
  2. TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
    Authors: Shambharkar Et al.
    BMC Complement Altern Med 2015;10:e0127480
  3. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
    Authors: Chang Et al.
    PLoS One 2013;34:1096

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