Catalog # Availability Size / Price Qty
EGTA | CAS No. 67-42-5 | Buffers, Chelators and Reagents
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Description: Calcium chelating agent

Chemical Name: Ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid

Product Details
Citations (6)
Reviews (2)

Biological Activity

EGTA is a calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.

Technical Data

Soluble to 100 mM in 1M NaOH
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes.
    Boullerne et al.
    J.Neurosci.Res., 2001;63:124
  2. Catalytic superoxide scavenging by metal complexes of the calcium chelator EGTA and contrast agent EHPG.
    Fisher et al.
    Biochem.Biophy.Res.Comms., 2004;323:163

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EGTA activates CRAC current via passive ER Ca2+ depletion in HEK293 cells co-expressing YFP-STIM1 and Orai1-CFP.
By Anonymous on 12/16/2018
Application: Species: Human

ER Ca2+ in HEK293 cells co-expressing YFP-STIM1 and Orai1-CFP was passively depleted with pipette solution, containing (in mM): 20 EGTA, 145 Cs-methanesulfonate, 8 NaCl, 5 MgCl2 and 10 HEPES, pH 7.2 with KOH.

EGTA inhibits 15d-PGJ2 induced TNFa production by cardiomyocytes
By Anonymous on 12/10/2018
Application: Species: Mouse

HL-1 cells were incubated with EGTA (5 mM) for 30 min prior to 15d-PGJ2 (15 µM) treatment for 4 h to follow TNFa concentrations in the cell culture medium. Addition of EGTA resulted in abolition of 15d-PGJ2 induced TNFa production.

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