Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50
= 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.
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All Tocris products are intended for laboratory research use only.
Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition.
Bessodes et al.
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.
Michie et al.
Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine.
Podzuweit et al.
The citations listed below are publications that use Tocris products. Selected citations for EHNA hydrochloride include:
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