EHNA hydrochloride

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EHNA hydrochloride | CAS No. 58337-38-5 | Deaminase Inhibitors
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Description: Adenosine deaminase inhibitor

Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride

Purity: ≥98%

Product Details
Citations (11)

Biological Activity

EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.

Technical Data

Soluble to 100 mM in water and to 100 mM in ethanol and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for EHNA hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for EHNA hydrochloride include:

11 Citations: Showing 1 - 10

  1. Physiology and effects of nucleosides in mice lacking all four adenosine receptors.
    Authors: Xiao Et al.
    PLoS Biol  2019;17:e3000161
  2. Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease.
    Authors: Yu Et al.
    Mol Cell Proteomics  2016;15:810
  3. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass
    Authors: Davidson Et al.
    PLoS One  2016;11:e0158981
  4. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.
    Authors: Li Et al.
    Am J Physiol Renal Physiol  2015;3:e00121
  5. Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA.
    Authors: Liu Et al.
    Nat Neurosci  2014;8:e84620
  6. Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents.
    Authors: Guerrero Et al.
    Chem Res Toxicol  2013;26:1361
  7. Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.
    Authors: Prakasam Et al.
    PLoS One  2012;303:F279
  8. Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices.
    Authors: Lindquist
    Neuroscience  2012;223:365
  9. Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
    Authors: Yang Et al.
    Eur J Immunol  2010;40:449
  10. Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats.
    Authors: Takahashi Et al.
    Br J Pharmacol  2010;161:1806


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