Catalog Number: 1261
Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride
Biological Activity
Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM). Also a potent inhibitor of adenosine deaminase. Suppresses spontaneous differentiation of human ESCs in feeder-free conditions. Also prevents directed neuronal differentiation.
Technical Data
  • M.Wt:
    313.83
  • Formula:
    C14H23N5O.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    58337-38-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition.
    Bessodes et al.
    Biochem.Pharmacol., 1982;31:879
  2. Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T-cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.
    Michie et al.
    Cell.Signal., 1996;8:97
  3. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl)adenine.
    Podzuweit et al.
    Cell.Signal., 1995;7:733
Citations:

The citations listed below are publications that use Tocris products. Selected citations for EHNA hydrochloride include:

6 Citations: Showing 1 - 6
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  1. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass
    Authors: Davidson Et al.
    PLoS One 2016;11:e0158981
  2. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances.
    Authors: Li Et al.
    Am J Physiol Renal Physiol 2015;3:e00121
  3. Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA.
    Authors: Liu Et al.
    Nat Neurosci 2014;8:e84620
  4. Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents.
    Authors: Guerrero Et al.
    Chem Res Toxicol 2013;26:1361
  5. Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.
    Authors: Prakasam Et al.
    PLoS One 2012;303:F279
  6. Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats.
    Authors: Takahashi Et al.
    Br J Pharmacol 2010;161:1806

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