EHop 016

Key Product Details

Product Description

EHop 016 is a Rac inhibitor (IC₅₀ = 1.1 μM). Exhibits some selectivity for Rac1 and Rac3 over Cdc42. Blocks the interaction of Rac with guanine nucleotide exchange factor Vav2 in breast cancer cell lines expressing high levels of Rac activity and inhibits activity of Rac downstream effector PAK1. Also inhibits mammary tumor growth and metastasis in mice.

Product Specifications for EHop 016

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for EHop 016

The following data is based on the product molecular weight 430.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.65 mL	23.23 mL	46.45 mL
2.5 mM	0.93 mL	4.65 mL	9.29 mL
5 mM	0.46 mL	2.32 mL	4.65 mL
25 mM	0.09 mL	0.46 mL	0.93 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Montalvo-Ortiz Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J.Biol.Chem. 2012 PMID: 22383527
• Castillo-Pichardo The Rac inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model. Transl.Oncol. 2014 PMID: 25389450

Product Documents for EHop 016