EHop 016

Catalog # Availability Size / Price Qty
EHop 016 | CAS No. 1380432-32-5 | Rho GTPase Inhibitors
1 Image
Description: Rac inhibitor

Chemical Name: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine

Purity: ≥98%

Product Details

Biological Activity

EHop 016 is a Rac inhibitor (IC50 = 1.1 μM). Exhibits some selectivity for Rac1 and Rac3 over Cdc42. Blocks the interaction of Rac with guanine nucleotide exchange factor Vav2 in breast cancer cell lines expressing high levels of Rac activity and inhibits activity of Rac downstream effector PAK1. Also inhibits mammary tumor growth and metastasis in mice.

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The Rac inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model.
    Castillo-Pichardo et al.
    Transl.Oncol., 2014;7:546
  2. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
    Montalvo-Ortiz et al.
    J.Biol.Chem., 2012;287:13228

Product Datasheets

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