EHT 1864

Tocris Bioscience | Catalog # 3872

Potent Rac family inhibitor
Tocris Bioscience

Key Product Details

Description

Potent Rac family inhibitor
View all Rho GTPase Inhibitors »

Product Description

EHT 1864 is an inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (KD values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β-amyloid peptide production in vivo.

Licensing Information

Sold for research use only under license from ExonHit Therapeutics S.A.

Product Specifications for EHT 1864

Molecular Weight

581.47

Formula

C25H27F3N2O4S.2HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

CAS Number

754240-09-0

PubChem ID

9938202

InChI Key

LSECOAJFCKFQJG-UHFFFAOYSA-N

SMILES

O=C1C=C(CN4CCOCC4)OC=C1OCCCCCSC3=CC=NC2=CC(C(F)(F)F)=CC=C23.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.63 20
DMSO 43.61 75

Preparing Stock Solutions for EHT 1864

The following data is based on the product molecular weight 581.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.29 mL 11.47 mL 22.93 mL
3.75 mM 0.46 mL 2.29 mL 4.59 mL
7.5 mM 0.23 mL 1.15 mL 2.29 mL
37.5 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 113 publications citing the usage of this product.

Product Documents for EHT 1864

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EHT 1864

For research use only

Customer Reviews for EHT 1864 (1)

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  • Rac inhibitor
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Brain slice
    Verified Customer | Posted 01/31/2018
    Used to block Rac but no effect seen. Can't say if the compound actually works or not.

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