Chemical Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Biological ActivityNaturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
Tewey et al.
Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism.
Ohashi et al.
Jpn.J.Cancer Res., 1995;86:819
Citations for Ellipticine
The citations listed below are publications that use Tocris products. Selected citations for Ellipticine include:
2 Citations: Showing 1 - 2
IDA is a broad-spectrum enterovirus replication inhibitor that selectively targets the virus internal ribosomal entry site.
Authors: Hou Et al.
J Gen Virol 2016;97:1122
Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.
Authors: Kishikawa Et al.
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Ellipticine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.