Catalog Number: 3357
Chemical Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Biological Activity
Naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism.
    Ohashi et al.
    Jpn.J.Cancer Res., 1995;86:819
  2. Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
    Tewey et al.
    J.Biol.Chem., 1984;259:9182

The citations listed below are publications that use Tocris products. Selected citations for Ellipticine include:

1 Citations: Showing 1 - 1

  1. Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.
    Authors: Kishikawa Et al.
    Oncotarget 2015;6:8339

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