EM 163

Catalog # Availability Size / Price Qty
EM 163 | CAS No. 1206480-93-4 | Cytokine Compounds
1 Image
Description: TIR-TIR interaction inhibitor

Chemical Name: 1-Methyl-2,5-bis[[[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide

Purity: ≥98%

Product Details

Biological Activity

EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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