EMD 386088 hydrochloride

Key Product Details

Product Description

EMD 386088 hydrochloride is a potent 5-HT₆ receptor agonist (EC₅₀ = 1.0 nM) that displays selectivity over other 5-HT receptors (IC₅₀ values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT₆, 5-HT_1D, 5-HT_1B, 5-HT_2A, 5-HT_2C, 5-HT₄, 5-HT_1A and 5-HT₇ receptors respectively). Shows moderate affinity at 5-HT₃ receptors (IC₅₀ = 34 nM).

Product Specifications for EMD 386088 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for EMD 386088 hydrochloride

The following data is based on the product molecular weight 283.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.53 mL	17.66 mL	35.31 mL
5 mM	0.71 mL	3.53 mL	7.06 mL
10 mM	0.35 mL	1.77 mL	3.53 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mattsson 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT₆ receptor agonists. Bioorg.Med.Chem.Lett. 2005 PMID: 16055331

Product Documents for EMD 386088 hydrochloride