EMD 386088 hydrochloride
Chemical Name: 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride
Biological ActivityEMD 386088 hydrochloride is a potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.
Mattsson et al.
Citations for EMD 386088 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for EMD 386088 hydrochloride include:
3 Citations: Showing 1 - 3
Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation.
Authors: Ly Et al.
ACS Chem Neurosci 2013;4:191
Excess of serotonin affects neocortical pyramidal neuron migration.
Authors: Riccio Et al.
Transl Psychiatry 2011;1:e47
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