EN6

Key Product Details

Product Description

EN6 is an activator of lysosomal vacuolar H⁺ ATPase (v-ATPase). EN6 covalently binds to the catalytic subunit of v-ATPase leading to increased acidification of lysosomes, inactivation of mTORC1 signaling and activation of autophagy in vivo. EN6 triggers entosis and promotes clearance of TDP43 protein aggregates in vitro.

Product Specifications for EN6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for EN6

The following data is based on the product molecular weight 368.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.15 mL	135.74 mL	271.49 mL
0.5 mM	5.43 mL	27.15 mL	54.30 mL
1 mM	2.71 mL	13.57 mL	27.15 mL
5 mM	0.54 mL	2.71 mL	5.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Su Role and dynamics of vacuolar pH during cell-in-cell mediated death. Cell Death Dis. 2021 PMID: 33483474
• Chung Covalent targeting of the vacuolar H⁺-ATPase activates autophagy via mTORC1 inhibition. Nat.Chem.Biol. 2019 PMID: 31285595

Product Documents for EN6