Catalog Number: 1055
Biological Activity
Endogenous peptide with an exceptionally high affinity (Ki = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).
Technical Data
  • M.Wt:
    610.67
  • Formula:
    C34H38N6O5
  • Sequence:
    YPWF

    (Modifications: Phe-3 = C-terminal amide)

  • Solubility:
    Soluble to 0.60 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    189388-22-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain.
    Goldberg et al.
    J.Pharmacol.Exp.Ther., 1998;286:1007
  2. Parallel stimulations of in vitro and in situ [35S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains.
    Kakizawa et al.
    Peptides, 1998;19:755
  3. Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes.
    Harrison et al.
    Peptides, 1998;19:749
  4. A potent and selective endogenous agonist for the μ-opiate receptor.
    Zadina et al.
    Nature, 1997;386:499
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Endomorphin-1 include:

2 Citations: Showing 1 - 2
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  1. Morphine-stimulated nitric oxide release in rabbit aqueous humor.
    Authors: Dortch-Carnes and Russell
    Am J Physiol Endocrinol Metab 2007;84:185
  2. RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance.
    Authors: Garzón Et al.
    Neuropsychopharmacology 2004;29:1091

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