Enoximone

Key Product Details

Product Description

Enoximone is an inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.

Product Specifications for Enoximone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Enoximone

The following data is based on the product molecular weight 248.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.14 mL	40.27 mL
5 mM	0.81 mL	4.03 mL	8.05 mL
10 mM	0.40 mL	2.01 mL	4.03 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Pacher and Stanek Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1999 PMID: 10935673
• Vroom Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 1996 PMID: 8672353
• Jung Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 2005 PMID: 15550574

Product Documents for Enoximone