Catalog Number: 6234
Alternate Names: BMS 200475, SQ 34676
Chemical Name: 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
Biological Activity
Potent and selective hepatitis B virus reverse transcriptase inhibitor (EC50 = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC50 values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.
Technical Data
  • M.Wt:
    277.28
  • Formula:
    C12H15N5O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    142217-69-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus.
    Innaimo et al.
    Antimicrob. Agents Chemother., 1997;41:1444
  2. BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
    Bisacchi et al.
    Bioorganic & Medicinal Chemistry Letters, 1997;7:127
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