Ephrin Protein Sampler Pack 3

50 ug each of rmEphrin-A1, rmEphrin-A2, rhEphrin-A3, rhEphrin-A4, rhEphrin-A5, rmEphrin-B1, rmEphrin-B2 and rhEphrin-B3 Fc Chimeras
  (1 citations)     
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Citations (1)
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Preparation and Storage
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Ephrin

The Eph receptors represent the largest family of receptor tyrosine kinases (RTK) in the human genome. Their ligands, the ephrins, are also cell surface bound proteins, thereby requiring cell-cell interaction for binding and signaling. The ephrin ligands are divided into two categories: the A class are tethered to the membrane by a GPI anchor, and the B class are transmembrane proteins. Likewise, the receptors are also divided into two categories based on sequence similarity and ligand specificity. Ephrin-A ligands bind EphA receptors and ephrin-B ligands bind EphB receptors, with the exception of EphA4 which binds both A and B-type ligands.

Eph/ephrin signaling is involved in vascular development, tissue-border formation, brain boundaries, cell migration, axon guidance, and synaptic plasticity. Eph/ephrin signaling activation generally results in repulsion of cells and often converges on the regulation of the cytoskeleton. Like most RTKs, ligand binding induces "forward" signaling, where a response occurs in the Eph receptor-containing cell. However, in some circumstances, this family can also exhibit "reverse signaling" where ephrins act as receptors responding to Eph signals, and ephrins signal back into their host cell.

  • Alternate Names:
    Ephrin
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Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citations: Showing 1 - 1

  1. A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus
    Authors: AK Gro beta kopf, A Ensser, F Neipel, D Jungnickl, S Schlagowsk, RC Desrosiers, AS Hahn
    PLoS Pathog., 2018;14(2):e1006912.  2018

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Recombinant Proteins
Description Application Cat# Citations Images  

Recombinant Mouse Ephrin-B2 Fc Chimera Protein, CF

Bind 496-EB 33
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Recombinant Human Ephrin-A5 Fc Chimera Protein, CF

Bind 374-EA 23
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Recombinant Mouse Ephrin-B1 Fc Chimera Protein, CF

Bind 473-EB 22
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Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF

Bind 602-A1 16
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Recombinant Human Ephrin-A3 Fc Chimera Protein, CF

Bind 359-EA 8
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Recombinant Mouse Ephrin-A2 Fc Chimera Protein, CF

Bind 603-A2 6
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Recombinant Human Ephrin-A4 Fc Chimera Protein, CF

Bind 369-EA 4
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