EPPTB

Tocris Bioscience | Catalog # 4518

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism
Tocris Bioscience

Key Product Details

Description

Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism
View all Trace Amine 1 (TA1) Receptor Antagonists »

Product Description

EPPTB is a trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

Product Specifications for EPPTB

Molecular Weight

378.39

Formula

C20H21F3N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide

CAS Number

1110781-88-8

PubChem ID

25175634

InChI Key

KLFVWQCQUXXLOU-UHFFFAOYSA-N

SMILES

O=C(NC3=CC(OCC)=CC=C3)C1=CC(C(F)(F)F)=C(N2CCCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.84 100
Ethanol 37.84 100

Preparing Stock Solutions for EPPTB

The following data is based on the product molecular weight 378.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for EPPTB

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EPPTB

For research use only

Customer Reviews for EPPTB (1)

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  • Only Specific to mouse TAAR1
    Name: Alex Voisey
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 12/31/2019
    only use for mouse tissues, all publications using this product are in mice
    1-5 uM in organ bath for rat isolated aortic rings
    EPPTB 4518

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