EPZ 015666

Catalog # Availability Size / Price Qty
6516/5
6516/25
Cat.No. 6516 - EPZ 015666 | C20H25N5O3 | CAS No. 1616391-65-1
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Description: Potent and selective PRMT5 inhibitor

Chemical Name: N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 22 nM, Ki = 5 nM). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases. Exhibits dose-dependent antitumor effects in multiple mantle cell lymphoma (MCL) xenograft models. Orally bioavailable.

Technical Data

M.Wt:
383.44
Formula:
C20H25N5O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1616391-65-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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