Catalog Number: 3823
Chemical Name: 4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid
Biological Activity
Antagonist of RARα receptors (IC50 = 31.2 nM). Displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively).
Technical Data
  • M.Wt:
    432.51
  • Formula:
    C29H24N2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    187400-85-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists.
    Kikuchi et al.
    Bioorg.Med.Chem.Lett., 2001;11:1215
  2. Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance.
    Ren et al.
    Mol.Cell.Biol., 2005;25:10591
  3. Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid.
    Somenzi et al.
    PLoS ONE, 2007;9:e836
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ER 50891 include:

1 Citations: Showing 1 - 1

  1. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
    Authors: Centritto Et al.
    J Reprod Dev 2015;7:950

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