ER 50891

Key Product Details

Product Description

ER 50891 is an antagonist of RARα receptors (IC₅₀ = 31.2 nM). Displays selective affinity for RARα (relative IC₅₀ values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively).

Product Specifications for ER 50891

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ER 50891

The following data is based on the product molecular weight 432.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.56 mL	23.12 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
10 mM	0.23 mL	1.16 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 24 publications citing the usage of this product.

• Ren Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance. Mol.Cell.Biol. 2005 PMID: 16287870
• Somenzi Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. PLoS ONE 2007 PMID: 17786207
• Kikuchi Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists. Bioorg.Med.Chem.Lett. 2001 PMID: 11354380

Product Documents for ER 50891