Chemical Name: 4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid
Biological ActivityER 50891 is an antagonist of RARα receptors (IC50 = 31.2 nM). Displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists.
Kikuchi et al.
Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance.
Ren et al.
Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid.
Somenzi et al.
PLoS ONE, 2007;9:e836
Citations for ER 50891
The citations listed below are publications that use Tocris products. Selected citations for ER 50891 include:
5 Citations: Showing 1 - 5
All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity.
Authors: Bi Et al.
Cell Biosci 2018;8:48
Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
Authors: Wang Et al.
J Mol Cell Biol 2017;9:338
Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme.
Authors: Li Et al.
Nat Commun 2017;8:ncomms14139
Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
Authors: Centritto Et al.
J Reprod Dev 2015;7:950
Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines.
Authors: Müller Et al.
PLoS One 2015;10:e0131467
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