Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Biological ActivityAntitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Dolma et al.
Cancer Cell, 2003;3:285
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Yagoda et al.
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Dixon et al.
Citations for Erastin
The citations listed below are publications that use Tocris products. Selected citations for Erastin include:
2 Citations: Showing 1 - 2
Metadherin enhances vulnerability of cancer cells to ferroptosis.
Authors: Bi Et al.
Cell Death Dis 2019;10:682
Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine.
Authors: Wei Et al.
Nat Commun 2019;10:3646
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