Antitumor agent; selective for cells expressing oncogenic RAS. Also Ferroptosis activator; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Dolma et al.
Cancer Cell, 2003;3:285
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Dixon et al.
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Yagoda et al.