Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone
Biological ActivityErastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Dolma et al.
Cancer Cell, 2003;3:285
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Yagoda et al.
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Dixon et al.
Citations for Erastin
The citations listed below are publications that use Tocris products. Selected citations for Erastin include:
2 Citations: Showing 1 - 2
Metadherin enhances vulnerability of cancer cells to ferroptosis.
Authors: Bi Et al.
Cell Death Dis 2019;10:682
Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine.
Authors: Wei Et al.
Nat Commun 2019;10:3646
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