Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
Biological ActivityEPAC inhibitor. Inhibits EPAC-mediated insulin releases from pancreatic β cells. Selective for EPAC over PKA. Decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.
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A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
Almahariq et al.
Citations for ESI 09
The citations listed below are publications that use Tocris products. Selected citations for ESI 09 include:
2 Citations: Showing 1 - 2
Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Authors: Perkins Et al.
A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
Authors: Wang Et al.
EMBO Mol Med 2015;11:2057
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