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ESI 09

4773 4 Citations Datasheet / COA / SDS
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4773/50
ESI 09 | CAS No. 263707-16-0 | EPAC Inhibitors
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Description: Epac inhibitor

Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

EPAC inhibitor. Inhibits EPAC-mediated insulin releases from pancreatic β cells. Selective for EPAC over PKA. Decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.

Technical Data

Formula:
C16H15ClN4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
263707-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
    Almahariq et al.
    Mol.Pharmacol., 2013;83:122

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Citations for ESI 09

The citations listed below are publications that use Tocris products. Selected citations for ESI 09 include:

4 Citations: Showing 1 - 4

  1. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
    Authors: Perkins Et al.
    Nat.Immunol.  2018;19:1309
  2. Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells.
    Authors: Drelich Et al.
    Viruses  2018;10
  3. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.
    Authors: Guichard Et al.
    PLoS Pathog  2017;13:e1006603
  4. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    EMBO Mol Med  2015;11:2057

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