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ESI 09

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Cat.No. 4773 - ESI 09 | C16H15ClN4O2 | CAS No. 263707-16-0
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Description: EPAC inhibitor

Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

EPAC inhibitor. Inhibits EPAC-mediated insulin releases from pancreatic β cells. Selective for EPAC over PKA. Decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.

Technical Data

Formula:
C16H15ClN4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
263707-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.
    Almahariq et al.
    Mol.Pharmacol., 2013;83:122

Product Datasheets

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Citation for ESI 09

The citations listed below are publications that use Tocris products. Selected citations for ESI 09 include:

1 Citation: Showing 1 - 1

  1. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    EMBO Mol Med  2015;11:2057

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