Catalog Number: 1847
Alternate Names: (-)-Eticlopride
Chemical Name: 3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamide hydrochloride
Biological Activity
Selective dopamine D2/D3 receptor antagonist (Ki values are 0.50 and 0.16 nM respectively). Antipsychotic.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Some in vitro receptor binding properties of [3H]eticlopride, a novel substituted benzamide, selective for dopamine-D2 receptors in the rat brain.
    Hall et al.
    Eur.J.Pharmacol., 1985;111:191
  2. Involvement of dopamine receptors in the antipsychotic profile of (-) eticlopride.
    Giuliani and Ferrari
    Physiol.Behav., 1997;61:563
  3. The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys.
    Claytor et al.
    Pharmacol.Biochem.Behav., 2006;83:456

The citations listed below are publications that use Tocris products. Selected citations for Eticlopride hydrochloride include:

6 Citations: Showing 1 - 6
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  1. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
    Authors: Cassar Et al.
    J Ginseng Res 2015;24:197
  2. Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
    Authors: Jensen
    PLoS One 2015;10:e0146154
  3. Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.
    Authors: Kramar Et al.
    Int J Neuropsychopharmacol 2014;39:1645
  4. Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats.
    Authors: Zhao Et al.
    Neuropsychopharmacology 2014;38:256
  5. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.
    Authors: Tønnesen Et al.
    PLoS One 2011;6:e17560
  6. Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy.
    Authors: Burgess Et al.
    Sleep 2010;33:1295

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