Etifoxine hydrochloride

Catalog # Availability Size / Price Qty
3113/10
3113/50
Etifoxine hydrochloride | CAS No. 56776-32-0 | Translocator Protein Ligands
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Description: Ligand of the translocator protein (TSPO); also GABAA receptor potentiator

Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride

Purity: ≥99%

Product Details
Reviews

Biological Activity

Potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.

Technical Data

M.Wt:
337.24
Formula:
C17H17ClN2O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
56776-32-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Etifoxine improves peripheral nerve regeneration and functional recovery.
    Girard et al.
    Proc.Natl.Acad.Sci., 2008;105:20505
  2. The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit.
    Hamon et al.
    Neuropharmacology, 2003;45:293

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