Potentiator of GABAA
receptor function in cultured neurons. Preferentially acts on β2
receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
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The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit.
Hamon et al.
Etifoxine improves peripheral nerve regeneration and functional recovery.
Girard et al.