Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride
Biological ActivityEtifoxine hydrochloride is a potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit.
Hamon et al.
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