Catalog Number: 3113
Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride
Biological Activity
Potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit.
    Hamon et al.
    Neuropharmacology, 2003;45:293
  2. Etifoxine improves peripheral nerve regeneration and functional recovery.
    Girard et al.
    Proc.Natl.Acad.Sci., 2008;105:20505
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