Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride
Biological ActivityEtifoxine hydrochloride is a potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Etifoxine improves peripheral nerve regeneration and functional recovery.
Girard et al.
The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit.
Hamon et al.
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