Catalog Number: 3947
Chemical Name: 4-[(3aR,4R,7S,7aS-rel)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Biological Activity
Negative control for endo-IWR 1 (Cat.No. 3532). 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway.
Technical Data
  • M.Wt:
    409.44
  • Formula:
    C25H19N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    1127442-87-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
    Lu et al.
    Bioorg.Med.Chem.Lett., 2009;19:3825
  2. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nature Chem.Biol., 2008;5:100
Tocris Small Molecules
Description Application Cat# Citations Images  

endo-IWR 1

3532 4  
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