Catalog Number: 3532
Chemical Name: [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Biological Activity
Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Negative control exo-IWR (Cat. No. 3947) available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
    Lu et al.
    Bioorg.Med.Chem.Lett., 2009;19:3825
  2. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nature Chem.Biol., 2008;5:100
Tocris Small Molecules
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exo-IWR 1

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