Chemical Name: [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Biological Activityendo-IWR 1 is an inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cells
Negative Control also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
Lu et al.
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
Chen et al.
Nature Chem.Biol., 2008;5:100
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex.
Kadoshima et al.
Generation of cerebral organoids from human pluripotent stem cells.
Lancaster et al.
Wnt inhibition promotes vascular specification of embryonic cardiac progenitors.
Reichman et al.
Citations for endo-IWR 1
The citations listed below are publications that use Tocris products. Selected citations for endo-IWR 1 include:
11 Citations: Showing 1 - 10
Establishment of porcine and human expanded potential stem cells.
Authors: Gao Et al.
Nat Cell Bio 2019;21:687
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
Authors: Garcia Et al.
Front Neurosci 2019;13:669
The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus.
Authors: Suzuki Et al.
Sci Rep 2018;8:15057
Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles.
Authors: Yamoah Et al.
Int J Nanomedicine 2018;13:6073
Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells.
PLoS One 2017;12(7):e0182051
Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
Authors: Kennedy Et al.
Proc Natl Acad Sci U S A 2016;113:3545
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Authors: Latos Et al.
Nat Commun 2015;6:7776
Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
Authors: Lindström Et al.
Mol Cell Biol 2015;3:e04000
WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
Authors: Suzuki Et al.
TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.
Authors: Iwata Et al.
Nat Protoc 2014;141:909
A conserved role for non-neural ectoderm cells in early neural development.
Authors: Cajal Et al.
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