endo-IWR 1

Catalog # Availability Size / Price Qty
3532/10
3532/50
endo-IWR 1 | CAS No. 1127442-82-3 | beta-Catenin Compounds
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Description: Wnt/β-catenin signaling inhibitor; axin stabilizer

Chemical Name: [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

Purity: ≥98%

Product Details
Citations (11)
Supplemental Products
Reviews

Biological Activity

Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Negative Control also available.

Technical Data

M.Wt:
409.44
Formula:
C25H19N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1127442-82-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for endo-IWR 1

The citations listed below are publications that use Tocris products. Selected citations for endo-IWR 1 include:

11 Citations: Showing 1 - 10

  1. Establishment of porcine and human expanded potential stem cells.
    Authors: Gao Et al.
    Nat Cell Bio  2019;21:687
  2. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
    Authors: Garcia Et al.
    Front Neurosci  2019;13:669
  3. The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus.
    Authors: Suzuki Et al.
    Sci Rep  2018;8:15057
  4. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles.
    Authors: Yamoah Et al.
    Int J Nanomedicine  2018;13:6073
  5. Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells.
    Authors: Kishimoto
    PLoS One  2017;12(7):e0182051
  6. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
    Authors: Kennedy Et al.
    Proc Natl Acad Sci U S A  2016;113:3545
  7. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
    Authors: Latos Et al.
    Nat Commun  2015;6:7776
  8. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
    Authors: Lindström Et al.
    Mol Cell Biol  2015;3:e04000
  9. WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
    Authors: Suzuki Et al.
    Development  2015;35:1763
  10. TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.
    Authors: Iwata Et al.
    Nat Protoc  2014;141:909

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