endo-IWR 1

  ( 6 citations )    
Product Datasheet
Catalog Number:3532
Chemical Name:[(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Negative Control also available.

Technical Data
  • M.Wt:
    409.44
  • Formula:
    C25H19N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    1127442-82-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for endo-IWR 1 include:

6 Citations: Showing 1 - 6
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  1. Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells.
    Authors: Kishimoto
    PLoS One  2017;12(7):e0182051
  2. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
    Authors: Kennedy Et al.
    Proc Natl Acad Sci U S A  2016;113:3545
  3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
    Authors: Latos Et al.
    Nat Commun  2015;6:7776
  4. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
    Authors: Lindström Et al.
    Mol Cell Biol  2015;3:e04000
  5. WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
    Authors: Suzuki Et al.
    Development  2015;35:1763
  6. TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.
    Authors: Iwata Et al.
    Nat Protoc  2014;141:909

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