Catalog Number: 3532
Chemical Name: [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Biological Activity
Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Negative Control also available.

Technical Data
  • M.Wt:
    409.44
  • Formula:
    C25H19N3O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    1127442-82-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
    Lu et al.
    Bioorg.Med.Chem.Lett., 2009;19:3825
  2. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nature Chem.Biol., 2008;5:100
Citations:

The citations listed below are publications that use Tocris products. Selected citations for endo-IWR 1 include:

4 Citations: Showing 1 - 4
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  1. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
    Authors: Latos Et al.
    Nat Commun 2015;6:7776
  2. Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
    Authors: Lindström Et al.
    Mol Cell Biol 2015;3:e04000
  3. WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
    Authors: Suzuki Et al.
    Development 2015;35:1763
  4. TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.
    Authors: Iwata Et al.
    Nat Protoc 2014;141:909
Tocris Small Molecules
Description Application Cat# Citations Images  

exo-IWR 1

3947  
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