Chemical Name: rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Biological Activityendo-IWR 1 is an inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cells and may be used in protocols for the generation of retinal pigment epithelial cells from hPSCs.
Negative Control also available.
endo-IWR 1 synthesized to Ancillary Material Grade also available.
For more information about how endo-IWR 1 may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
Chen et al.
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
Lu et al.
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex.
Kadoshima et al.
Generation of cerebral organoids from human pluripotent stem cells.
Lancaster et al.
Wnt inhibition promotes vascular specification of embryonic cardiac progenitors.
Reichman et al.
Citations for endo-IWR 1
The citations listed below are publications that use Tocris products. Selected citations for endo-IWR 1 include:
26 Citations: Showing 1 - 10
Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling.
Authors: Erika Et al.
Sci Rep 2023;13:3186
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
Authors: W Hayes Et al.
JCI Insight 2022;7
Suspension culture promotes serosal mesothelial development in human intestinal organoids.
Authors: Capeling Et al.
Cell Rep. 2022;38:110379
Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
Authors: Jia Et al.
J Neurochem 2022;161:463-477
Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human.
Authors: Min Et al.
Nat Commun 2022;13:3883
A specialized bone marrow microenvironment for fetal haematopoiesis.
Authors: Martin Et al.
Nat Commun 2022;13:1327
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells.
Authors: Timothy C Et al.
An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates.
Authors: Alexandre P Et al.
Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Authors: Esra Et al.
Methods Mol Biol 2021;2520:161-170
SEM/FIB Imaging for Studying Neural Interfaces.
Authors: Amos Et al.
Dev Neurobiol 2020;80:305-315
Electrophysiologic Characterization of Developing Human Embryonic Stem Cell-Derived Photoreceptor Precursors.
Authors: Alon Et al.
Invest Ophthalmol Vis Sci 2020;61:44
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Authors: Geoffrey Et al.
Cell Rep 2020;32:107922
Vascularized human cortical organoids (vOrganoids) model cortical development in vivo.
Authors: Le Et al.
PLoS Biol 2020;18:e3000705
TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease.
Authors: Eunjeong Et al.
Proc Natl Acad Sci U S A 2020;117:29001-29012
Establishment of porcine and human expanded potential stem cells.
Authors: Gao Et al.
Nat Cell Bio 2019;21:687
Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.
Authors: Garcia Et al.
Front Neurosci 2019;13:669
The role of acetyltransferases for the temporal-specific accessibility of β-catenin to the myogenic gene locus.
Authors: Suzuki Et al.
Sci Rep 2018;8:15057
hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate.
Authors: Ali H Et al.
Cell Stem Cell 2018;23:60-73.e6
Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles.
Authors: Yamoah Et al.
Int J Nanomedicine 2018;13:6073
Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells.
PLoS One 2017;12(7):e0182051
Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
Authors: Kennedy Et al.
Proc Natl Acad Sci U S A 2016;113:3545
Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.
Authors: Latos Et al.
Nat Commun 2015;6:7776
Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
Authors: Lindström Et al.
Mol Cell Biol 2015;3:e04000
WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.
Authors: Suzuki Et al.
TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.
Authors: Iwata Et al.
Nat Protoc 2014;141:909
A conserved role for non-neural ectoderm cells in early neural development.
Authors: Cajal Et al.
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