Inhibitor of Wnt signaling. Induces an increase in Axin2 protein levels; promotes β
-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Negative control exo-IWR
(Cat. No. 3947) available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
Lu et al.
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
Chen et al.
Nature Chem.Biol., 2008;5:100
The citations listed below are publications that use Tocris products. Selected citations for endo-IWR 1 include:
Showing Results 1 - 4 of 4